Mechanical circulatory support challenges in pediatric and (adult) congenital heart disease

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Pediatric mechanical circulatory support: challenges and opportunities.

Cardiomyopathy is rare in the pediatric age group, with an annual incidence of only 6 to 12 cases per million children.1–3 In addition to the genetic and acquired cardiomyopathies, heart failure in children also occurs as a complication of congenital cardiac anomalies, ranging from hypoplastic left heart syndrome to tetralogy of Fallot. In the registry of the International Society of Heart and ...

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Pediatric Mechanical Circulatory Support

Mechanical circulatory support (MCS) in the pediatric heart failure population has a limited history especially for infants, and neonates. It has been increasingly recognized that there is a rapidly expanding population of children diagnosed and living with heart failure. This expanding population has resulted in increasing numbers of children with medically resistant end-stage heart failure. T...

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Mechanical Circulatory Support for End-Stage Heart Failure in Repaired and Palliated Congenital Heart Disease

Approximately one in one hundred children is born with congenital heart disease. Most can be managed with corrective or palliative surgery but a small group will develop severe heart failure, leaving cardiac transplantation as the ultimate treatment option. Unfortunately, due to the inadequate number of available donor organs, only a small number of patients can benefit from this therapy, and m...

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Heart transplantation with or without prior mechanical circulatory support in adults with congenital heart disease.

OBJECTIVES Recent analyses establish that heart transplantation is increasing among adults with congenital heart disease (ACHD), but the effects of pretransplant mechanical circulatory support (MCS) on perioperative and post-transplant outcomes have not been examined in the ACHD population. METHODS Scientific Registry of Transplant Recipients data on all adult heart transplants from September...

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Pediatric cardiology and adult congenital heart disease

Background: The major limitation of the anthracyclines (AC) class of cancer chemotherapeutic drugs is progressive cardiotoxicity. Currently, patients receiving AC are monitored by echocardiographic measurement of shortening fraction (SF). Other indices, though more sensitive, are technically difficult to obtain. There is a need for a sensitive and rapid biomarker to detect cardiac injury in the...

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ژورنال

عنوان ژورنال: Current Opinion in Organ Transplantation

سال: 2018

ISSN: 1087-2418

DOI: 10.1097/mot.0000000000000522